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Although mean arterial pressure (MAP) is the primary driving force for tissueperfusion, cerebral blood flow (CBF) is determined by multiple intrinsic factors. (2000) Assessment ofcerebral blood flow in Alzheimer’s disease by spin-labeled mag-netic resonance imaging. Taking blood pressure: Too important to trust to humans? Cleveland Clinic Journal of Medicine, 77(10), 683–688. In addition, the nurse can usephysician- and nurse-prescribed interventions to minimize thecomplications of these problems. Each cell is separatedby a narrow space containing external (basal)lamina and an extremely attenuated process ofa fibroblast. Individuals who lack positive social stimula-tion are at higher risk for stress, depression, and loneliness(Cacioppo et al., 2010), which correlates with an increasedrisk for cognitive decline (Conroy et al., 2010; Panza et al.,2010). Stenson PD, Mort M, Ball EV, Shaw K, Phillips A, Cooper DN (2014) The human gene muta-tion database: building a comprehensive mutation repository for clinical and molecular genet-ics, diagnostic testing and personalized genomic medicine

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